Fig. 5: Conformational changes in MCHR1 and MCHR2 upon activation.
From: Mechanisms of ligand recognition and activation of melanin-concentrating hormone receptors
a, b Structural superposition between cryo-EM structures of MCH-bound MCHR complexes and the AlphaFold2-predicted inactive models from the GPCR databank is shown from the side view and the cytoplasmic view. c Structural alignment highlighting the toggle switch mechanism. d Depiction of shifts in H/F2.53, D3.32, and Y7.43 at the base of the binding pocket. e‒g Illustration of the conserved motifs in MCH-activated MCHRs: DRY motif (e); NPxxY motif (f); PIF motif (g).
