Fig. 1: Cryo-EM structure of MPXV E5-AMPPNP complex.
From: Structural and functional insights into the helicase protein E5 of Mpox virus
a Domain architecture of MPXV E5. b Overall folding and assembly of MPXV E5 in the E5-AMPPNP structure. c The central ring formed by the D5N, Linker, and SF3 helicase domains, which are shown as cartoon in different colors. D5N and SF3 domains are shown as surface in gray. The bound AMPPNPs are shown as spheres. d The relative orientations of the AEP and ZnD domains, which are shown as cartoon. D5N domains are shown as surface in gray.
