Fig. 1: The SARs of new hybrids of macrolides and quinolones.
From: Synthetic macrolides overcoming MLSBK-resistant pathogens
a Structures of the first-, second- and third-generation marketed erythromycins. b Structures of the representative macrolones MCX-219 and MCX-190. c MICs (μg/mL) of the selected synthetic macrolides. EryS erythromycin sensitive, AZMS azithromycin sensitive, TEL telithromycin, CLA clarithromycin, CIP ciprofloxacin. The strains 07P390, PU09, 12-206, 15B196, and PU32 are erythromycin-resistant clinical isolates encoding various resistant genes.
