Fig. 5: TMD rearrangements upon GAT and Ca2+ binding.
From: Structural basis for allosteric agonism of human α7 nicotinic acetylcholine receptors
a Superimposition of the TMDs from the apo-α7 (gray, PDB: 7EKI) and GAT-open-state (orange) structures. b Superimposition of the TMDs from the GAT-open-state (orange) and GAT-desensitized-state (blue) structures. c Superimposition of the TMDs from GAT-desensitized-state (blue) and the apo-α7 (gray) structures. d A view of M2 helices from the extracellular space in the apo-α7 structure. The corresponding distances between adjacent α-carbons of 9’ (L270) and 16’ (L277) are given in Å. e, f A view of M2 helices from the extracellular space in the GAT-open-state (e) or GAT-desensitized-state (f) structure.
