Fig. 2: BA.5/BF.7 and XBB infections increase the neutralizing potency of JN.1 antibodies.

a, b Spike RBD-specific IgG ELISAs were performed using sera collected at the indicated times against RBD proteins of SARS-CoV-2 WT, BA.5, XBB.1.5, JN.1, and KP.3 variants. Dashed lines indicate the limit of detection (IgG titer = 500). GMTs are labeled as black lines and shown above each column, with fold-changes and significance compared with the variant having the highest titer shown on the top. c, d Neutralization potency was calculated by dividing the pVNT₅₀ values by the RBD IgG endpoint titers. Mean values are labeled as black lines and shown above each column, with fold-changes and significance compared with T1 shown on the top. e Comparison of the neutralization potency between single infection group and double infection group. Mean values are labeled as dots, with significance shown on the top. *P < 0.05, **P < 0.01, ***P < 0.001; ns, not significant.