Fig. 2: Systemic MT1-MMP depletion alleviates aging-associated cognitive impairment.
From: MT1-MMP inhibition rejuvenates ageing brain and rescues cognitive deficits in obesity
a Schematic diagram of object location test. b Time spent exploring the displaced object expressed as the preference for the displaced object (%) from 2-month-old (young) to 18-month-old (aged) WT and Mmp14+/− mice. One-way ANOVA followed by Fisher’s LSD post hoc test (n = 6 mice per group). c Schematic diagram of Barnes maze test. d, e Percentage of total time spent in the target quadrant (d) and distance traveled to the target hole (e) in Barnes maze test. One-way ANOVA followed by Tukey’s multiple comparisons test (n = 10 young, n = 10 Mmp14+/− young, n = 11 aged, n = 7 Mmp14+/− aged mice). f Schematic diagram of contextual fear conditioning test. g Percentage of freezing time during a contextual fear conditioning test performed by young and aged WT and Mmp14+/− mice. One-way ANOVA followed by Fisher’s LSD post hoc test (n = 6 mice per group). h, i LTP in the CA1 hippocampal region quantified as the change in fEPSP (h) and the average of fEPSP (i) from young and aged WT and Mmp14+/− mice. One-way ANOVA followed by Tukey’s multiple comparisons test (n = 5 mice per group). Data are expressed as mean ± SEM, and each data point represents individual mouse.
