Fig. 5: ACSL4-K500R mutation abrogates the effect of SUMO2-K11la on ferroptosis. | Cell Discovery

Fig. 5: ACSL4-K500R mutation abrogates the effect of SUMO2-K11la on ferroptosis.

From: Ferroptosis-induced SUMO2 lactylation counteracts ferroptosis by enhancing ACSL4 degradation in lung adenocarcinoma

Fig. 5: ACSL4-K500R mutation abrogates the effect of SUMO2-K11la on ferroptosis.

a ACSL4-K500R mutation abolished SUMOylation in LUAD cells. b–d K500R accelerated ubiquitination-dependent ACSL4 degradation and nullified SUMO2-K11R-induced stabilization in A549 cells. e–h K500R mutants conferred ferroptosis resistance and abolished the ferroptosis-promoting effect of K11R, as evidenced by cytotoxicity assays (e), lipid peroxidation detection (f), MDA (g), and GSH/GSSG measurements (h). Data were analyzed by one-way ANOVA and were presented by mean ± SD.

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