Fig. 2: Establishment and validation of a three-level classification system based on exosomes from CP patients in the derivation cohort. | Cell Discovery

Fig. 2: Establishment and validation of a three-level classification system based on exosomes from CP patients in the derivation cohort.

From: Integrated transcriptome profiling of plasma exosomes reveals molecular stratification of exocrine and endocrine disorders and S100A8-mediated cell interactions in chronic pancreatitis

Fig. 2: Establishment and validation of a three-level classification system based on exosomes from CP patients in the derivation cohort.

a Flow diagram of the acquisition of online human CP single-cell sequencing data. b Uniform manifold approximation and projection (UMAP) of cell types identified in human CP single-cell sequencing data. c Dot plot of marker genes in each cell type. d UMAP plot of the expression of exocrine or endocrine signatures. e Four-quadrant diagram showing the expression of exocrine or endocrine signature in each sample, divided into HCs or CP patients. f Left: concept map of the COCA classification method. Right: flow diagram of the acquisition of online human CP single-cell sequencing data. g Four-quadrant diagram showing the expression of exocrine or endocrine signatures in each sample, divided into HCs or each subtype of CP patients. h Expression of the exocrine or endocrine signature among HCs or each subtype of CP. i Kaplan–Meier curve of steatorrhea development in non-steatorrhea CP patients stratified by COCA subtype during follow-up in the derivation cohort. j Kaplan–Meier curve of diabetes development in non-diabetic CP patients stratified by COCA subtype during follow-up in the derivation cohort.

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