Fig. 2: Immunologic alterations exhibit increased macrophages across most tissues in myopic mice. | Cell Discovery

Fig. 2: Immunologic alterations exhibit increased macrophages across most tissues in myopic mice.

From: Single-cell profiling reveals a shared proinflammatory macrophage signature across multiple organs in myopia

Fig. 2

a t-SNE plots showing that immune cells accumulated in the tissues of myopic mice. Left, t-SNE plot highlighting the CD45-positive cells. Middle, t-SNE plots of major immune cell types. Right, t-SNE plots and proportions of major immune cell types in the control and myopia groups. b Heatmap illustrating distinct expression patterns in different immune cells based on cell type-specific marker genes. c Comparison of the percentages of major immune cell types in each tissue between the control and myopia groups. M macrophage, AM alveolar macrophage, IM interstitial macrophage, KC Kupffer cell, MIC microglia, T T cell, B B cell, NK natural killer cell, DC dendritic cell, EO eosinophil, NEU neutrophil. For tissue type: PVC primary visual cortex, LGN lateral geniculate nucleus, HPC hippocampus, PBMC peripheral blood mononuclear cell, BM bone marrow, Si small intestine, Li large intestine, AG adrenal gland.

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