Fig. 4: Proinflammatory macrophage phenotype is shared across multiple tissues in myopic mice. | Cell Discovery

Fig. 4: Proinflammatory macrophage phenotype is shared across multiple tissues in myopic mice.

From: Single-cell profiling reveals a shared proinflammatory macrophage signature across multiple organs in myopia

Fig. 4

a Volcano plots highlighting distinctive markers of 17 macrophage subsets. b t-SNE plots displaying 17 macrophage subsets and their distributions in different tissues. c Percentages of each macrophage subset in the control and myopia groups, with comparisons across tissues. Compared to controls, the myopia group showed significantly increased proinflammatory subsets (Macro_Apoc1, Macro_S100a, Macro_Ifitm3/6, etc.) and decreased anti-inflammatory subsets (Macro_Chil3, Macro_Glul, etc.). PVC primary visual cortex, LGN lateral geniculate nucleus, HPC hippocampus, PBMC peripheral blood mononuclear cell, BM bone marrow, Si small intestine, Li large intestine, AG adrenal gland.

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