Fig. 7: Inhibition of hypoxia pathway can suppress the proinflammatory phenotype of macrophages in multiple tissues. | Cell Discovery

Fig. 7: Inhibition of hypoxia pathway can suppress the proinflammatory phenotype of macrophages in multiple tissues.

From: Single-cell profiling reveals a shared proinflammatory macrophage signature across multiple organs in myopia

Fig. 7

a Diagram illustrating the protocol for salidroside injection during myopia modeling in mice. “i.p.” denotes intraperitoneal injection. b The refraction at baseline and after 4 weeks of myopia modeling in the normal saline and salidroside groups. Mice injected with salidroside exhibited less myopia compared to those receiving normal saline. c, d Flow-cytometric quantification showed significantly lower ratios of macrophages (CD68+), Car1+ macrophages, HIF-1α+ macrophages in the large intestine (Li), liver, and kidney of the myopic mice compared with those without myopia (n = 3). ***P < 0.001, *P < 0.05; ns no significance.

Back to article page