Table 2 Safety and effectiveness in the surgery group (n = 21).

From: Surgery after induced anti-PD-L1 therapy and chemotherapy for stage IIII small-cell lung cancer: a phase 2 trial (LungMate-005)

Characteristics

Surgery (n = 21)

Time from last dose chemotherapy to surgery, days

Mean ± SD: 40.24 ± 11.19

IQR: 39.00 (32.00, 46.00)

R0 resection

100%

n (%) with surgical approaches,

 RATS lobectomy

2 (9.5%)

 VATS lobectomy

11 (52.3%)

 VATS bi-lobectomy

2 (9.5%)

 VATS double sleeve resection (Bronchovascular)

1 (4.8%)

 Lobectomy

2 (9.5%)

 Tracheal sleeve resection

1 (4.8%)

 Double sleeve resection (Bronchovascular)

1 (4.8%)

 Intrapericardial bi-lobectomy

1 (4.8%)

Operation time, hours

Mean ± SD: 2.07 ± 0.62

IQR: 2.00 (1.50, 2.50)

Intraoperative blood loss, mL

Mean ± SD: 63.81 ± 42.01

IQR: 50.00 (50.00, 50.00)

Blood transfusion, mL

0 (no one received blood transfusion)

Hospitalization time, days

Mean ± SD: 5.38 ± 0.42

IQR: 5.00 (4.00, 7.00)

Chest tube removal time, days

Mean ± SD: 11.67 ± 5.62

IQR: 11.00 (6.50, 15.00)

30-days mortality

0

90-days mortality

0

n (%) with complications,

4 (19.0%)

 Bronchopleural fistula

2 (9.5%)

 Subcutaneous emphysema

2 (9.5%)

n (%) with residual viable tumour

 

 0%

9 (42.9%)

 0–10%

4 (19.0%)

 > 10%

8 (38.1%)

Residual viable tumour, %

Mean ± SD: 18 ± 27

IQR: 5.00 (0.00, 20.00)

Decrease in sum of lesion diameter, %

Mean ± SD: 59.84 ± 21.98

IQR: 62.48 (40.44, 78.78)

n (%) with TNM downstaging

17 (81.0%)

n (%) with T downstaging

19 (90.5%)

n (%) with N downstaginga

15 (71.4%)

 N3 to N0

3 (75.0%)

 N3 to N1

1 (25.0%)

 N2 to N0

3 (42.9%)

 N2 to N2

4 (57.2%)

 N1 to N0

8 (88.9%)

 N1 to N1

1 (11.1%)

  1. a The diameter of the lymph node (N2) was smaller than 15 mm. PET-CT indicated that lymph nodes (N2) were negative before surgery; lymph nodes (N3) were confirmed to be pathologically negative before surgery. No systematic dissection of the lymph nodes (N3) was performed. lymph nodes (N3) were pathologically confirmed negative by endobronchial ultrasound, supraclavicular lymph node puncture biopsy, or mediastinoscopy.