Fig. 4: Stamp-seq revealed a chemoimmunotherapy response-related fibroblastic environment. | Cell Discovery

Fig. 4: Stamp-seq revealed a chemoimmunotherapy response-related fibroblastic environment.

From: Integrating single-nucleus barcoding with spatial transcriptomics via Stamp-seq to reveal immunotherapy response-enhancing functional modules in NSCLC

Fig. 4

a UMAP visualization of the fibroblast distribution across all samples, stratified by NpCR and pCR groups. b Heatmap depicting the district distribution preference of reclustered fibroblast subsets across all samples, quantified by the Ro/e score. The relative abundance of each cancer-associated fibroblast (CAF) subset within districts is shown for patients with distinct therapeutic responses (pCR and NpCR), with column normalization applied. c Spatial mapping of snRNA-seq profiles in sample D5, annotated by cell type, alongside the corresponding H&E-stained section of the profiled region. d Radar plot displaying the average distance of each cell type from the tertiary lymphoid structure (TLS) core in sample D5 of the T24 cohort. Three highly clustered TLS regions within the T24 sample were analyzed (Supplementary Fig. S8b). Embedded violin plots illustrate the radial distribution of all cells within each cell subtype.

Back to article page