Fig. 8 | Cell Research

Fig. 8

From: PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1–Parkin-mediated mitophagy

Fig. 8

Illustration of the novel function of PTEN-L as a protein phosphatase in suppression of mitophagy. PTEN-L is able to counteract PINK1-mediated ubiquitin phosphorylation (pSer65-Ub), which then leads to prevention of Parkin recruitment to damaged mitochondria, reduction of pSer65-Parkin level and maintenance of Parkin in its closed inactive conformation to impair Parkin E3 ligase activity, all resulting in the disruption of the feedforward loop to inhibit mitophagy

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