Fig. 1 | Cell Research

Fig. 1

From: cGAS activation in phased droplets

Fig. 1

Cytosolic DNA and cGAS form liquid droplets, which function as micro reactors in which the enzyme and reactants are concentrated to greatly enhance the production of cGAMP.7 cGAMP transduces signals to the ER-localized adaptor protein STING. STING recruits and activates the kinase TBK1, which then activates the transcription factor IRF3 to induce type I IFNs.1,2

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