Fig. 3
From: A novel m6A reader Prrc2a controls oligodendroglial specification and myelination
Effects of Prrc2a on longevity, motor behavior, and cognition. a Kaplan–Meier survival curves. Statistical significance was determined by the log rank test (***P < 0.001; f/f n = 29, f/ + ;Nes n = 27, f/f;Nes n = 20). b The latency of 3-month-old mice on the Rota-Rod (one-way ANOVA followed Tukey test, *P < 0.05, f/f, n = 29, f/ + ; Nes n = 24, f/f; Nes n = 14). c Grip strength analysis of 3-month-old mice with indicated genotypes (one-way ANOVA followed Tukey test, *P < 0.05, **P < 0.01, f/f, n = 32, f/ + ; Nes n = 24, f/f; Nes n = 15). d The mean escape latency (± SEM) for mice to reach the platform in the visible version of the water maze is plotted against the day of the experiment (f/f vs. f/ + ; Nes, P = 0.8972, F = 0.01688; f/f vs. f/f; Nes, P = 0.0999, F = 2.860; f/ + ; Nes vs. f/f; Nes, P = 0.0674, F = 3.570. Two-way ANOVA followed by Bonferroni test. f/f n = 23, f/ + ;Nes n = 23, f/f;Nes n = 13). e The mean escape latency ( ± SEM) for mice to reach the platform in the hidden version of the water maze is plotted against the day of the experiment (f/f vs. f/ + ; Nes, P = 0.0630, F = 3.639; f/f vs. f/f; Nes, P < 0.0001, F = 23.10; f/ + ; Nes vs. f/f; Nes, P = 0.0050, F = 8.992. Two-way ANOVA followed by Bonferroni test. f/f n = 23, f/ + ;Nes n = 23, f/f;Nes n = 13). f The mean traveled distance ( ± SEM) for mice to reach the platform in the hidden version of the water maze is plotted against the day of the experiment (f/f vs. f/ + ; Nes, P = 0.3979, F = 0.7289; f/f vs. f/f; Nes, P = 0.0097, F = 7.509; f/ + ; Nes vs. f/f; Nes, P = 0.0615, F = 3.740. Two-way ANOVA followed by Bonferroni test. f/f n = 23, f/ + ;Nes n = 23, f/f;Nes n = 13). g Probe trial was performed 24 h after the last training session by removing the platform. Probe model and representative vertical views of the tracks of mice with indicated genotypes were shown. h Time spent in the target quadrant during probe trial (one-way ANOVA followed Tukey test, *P < 0.05, **P < 0.01, f/f, n = 23, f/ + ; Nes n = 23, f/f; Nes n = 13). i Traveled distance in the target quadrant during probe trial (one-way ANOVA followed Tukey test, **P < 0.01, ***P < 0.001, f/f, n = 23, f/ + ; Nes n = 23, f/f; Nes n = 13). j The number of platform crossing from the same group of mice tested in the probe trial (one-way ANOVA followed Tukey test, *P < 0.05, ***P < 0.001, f/f, n = 23, f/ + ; Nes n = 23, f/f; Nes n = 13). The water maze behavior was tested in 6-month-old mice
