Fig. 10
From: Cortical branched actin determines cell cycle progression
Cortical branched actin controls the G1/S transition. The formation of cortical branched actin by ARPC1B-containing Arp2/3 complexes is under the control of the RAC/WAVE/ARPIN pathway. ARPC1B-containing complexes are specifically sensed by CORO1B, which signals S-phase entry. In contrast, ARPC1A-containing complexes are critical for endosomal branched actin, but do not affect cell cycle progression. Cortical branched actin integrates proliferation signals from soluble growth factors and mechanotransduced adhesion cues
