Fig. 6
In vivo efficacy of the lFVII against XDR P. aeruginosa infection. a–c Decreased bacterial load in peritoneal fluid (a), liver (b), and spleen (c) by injecting lFVII. Thirty minutes after intraperitoneal inoculation of 7 × 107 CFU of the XDR P. aeruginosa PA4, groups of six mice were injected intraperitoneally with saline, meropenem (2.5 mg/kg), polymyxin B, and lFVII. The dose of polymyxin B and lFVII were increased as indicated. Bacterial titers remaining in peritoneal fluid, liver and spleen were assayed at 24 h post injection of different agents. Bars indicate the means (n = 6). *P < 0.05 and **P < 0.01, significantly different from the saline-injected group. d Enhanced resistance to the XDR P. aeruginosa PA4 by injecting lFVII in mice. Thirty minutes after intraperitoneal inoculation of 9.0 × 107 CFU of P. aeruginosa PA4, groups of six mice were injected intraperitoneally with saline, polymyxin B, and lFVII. The dose of lFVII was the same as those in a–c
