Table 1 Antibacterial activities of lFVII, polymyxin B and meropenem against a range of Gram-negative bacteria
Bacterial type | Code/name | lFVII (nM) | Polymyxin B (nM) | Meropenem (nM) | |||
|---|---|---|---|---|---|---|---|
MHB | TBS | MHB | TBS | MHB | TBS | ||
A. baumannii | ATCC 19606 | 462.49 ± 66.55 | 10.23 ± 2.22 | 422.57 + 115.25 | 1843.94 ± 76.83 | 453.70 ± 3.43 | >450,000 |
K. peneumoniae | ATCC 4352 | 409.63 ± 34.01 | 9.84 ± 3.44 | 514.77 + 184.39 | 1690.28 ± 153.66 | 460.56 ± 19.43 | >450,000 |
P. aeruginosa | ATCC 27853 | 411.46 ± 13.93 | 15.26 ± 4.41 | 457.14 + 157.50 | 3726.30 ± 268.91 | 811.41 ± 102.85 | >450,000 |
E. cloacae | Y1 | 449.01 ± 37.59 | 12.59 ± 0.17 | 414.89 + 107.56 | 1613.45 ± 76.83 | 342.85 ± 114.28 | >450,000 |
P. aeruginosa | PA3 (XDR) | 449.01 ± 37.59 | 12.59 ± 0.17 | 418.73 ± 119.09 | 2185.84 ± 733.73 | NT | NT |
P. aeruginosa | PA4 (XDR) | 528.27 ± 164.03 | 12.00 ± 0.19 | 422.57 ± 107.56 | 2381.76 ± 845.14 | NT | NT |
A. baumannii | Ab3 (XDR) | 373.01 ± 21.87 | 4.27 ± 1.38 | 145.98 ± 53.78 | 1759.43 ± 145.98 | NT | NT |
A. baumannii | Ab5 (XDR) | 874.06 ± 16.33 | 7.67 ± 2.82 | 276.59 ± 46.10 | 3518.85 ± 215.13 | NT | NT |
A. baumannii | Ab16 (XDR) | 363.38 ± 3.72 | 3.25 ± 0.33 | 145.98 ± 46.10 | 1805.53 ± 268.91 | NT | NT |
A. baumannii | Ab18 (XDR) | 375.23 ± 2.62 | 4.66 ± 1.58 | 145.98 ± 38.42 | 1567.35 ± 84.51 | NT | NT |
A. baumannii | Ab30 (XDR) | 413.65 ± 41.20 | 5.13 ± 2.00 | 138.30 ± 30.73 | 1982.24 ± 61.46 | NT | NT |
A. baumannii | Ab35 (XDR) | 374.03 ± 10.54 | 5.00 ± 1.91 | 149.05 ± 4.61 | 1528.93 ± 69.15 | NT | NT |
A. baumannii | Ab42 (XDR) | 401.26 ± 43.51 | 4.01 ± 0.95 | 142.14 ± 34.57 | 1759.43 ± 7.68 | NT | NT |
A. baumannii | Ab46 (XDR) | 377.36 ± 4.72 | 3.49 ± 0.55 | 130.61 ± 53.78 | 1882.36 ± 345.74 | NT | NT |
A. baumannii | Ab48 (XDR) | 365.30 ± 5.52 | 3.35 ± 0.32 | 130.61 ± 46.10 | 2593.04 ± 1018.01 | NT | NT |
