Fig. 3: Comparison of the peptide-binding pocket of GLP-2R with other class B GPCRs.

The binding cavity of GLP-2R is compared with that of GLP-1-bound GLP-1R (PDB code: 5VAI),¹³ ExP5-bound GLP-1R (PDB code: 6B3J),¹⁷ glucagon-bound GCGR (PDB code: 6LMK)¹⁸ and LA-PTH-bound PTH1R (PDB code: 6NBF).¹⁹