Fig. 6: Family-wide comparison of ECL1 conformations.
From: A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor
a Scatter plot of ECL1 from 9 class B GPCRs. x axis shows the interface area between ECL1 and agonist, and y axis is the height of ECL1. b Structural comparison of diversified ECL1 conformations among class B GPCRs. All structures are superimposed on the GLP-1-bound GLP-1R (PDB: 5VAI)13 using the Cα carbons of the residues in the TM2–3–4. The locations of the membrane planes predicted by OPM (Orientations of Proteins in Membranes)54 are shown as black dashed lines. The height of ECL1 is defined as the maximum vertical distance of Cα carbon relative to the membrane layer, while the interface areas were calculated using freeSASA.53
