Fig. 6: β-Arrestin-2 mediates the pathological activation of the AT1 receptor aggravated by COMP deficiency. | Cell Research

Fig. 6: β-Arrestin-2 mediates the pathological activation of the AT1 receptor aggravated by COMP deficiency.

From: Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury

Fig. 6: β-Arrestin-2 mediates the pathological activation of the AT1 receptor aggravated by COMP deficiency.

a Representative images of the aortic morphology in COMP–/– or COMP–/–β-arrestin-2–/– mice infused with AngII (1000 ng/kg/min) for 28 days. b Incidence of AngII-induced AAA (COMP–/–: 10/11; COMP–/–β-arrestin-2–/–: 0/7). *P < 0.05 by χ2 test. c The maximal abdominal aortic diameters. COMP–/– + AngII, n = 11; COMP–/–β-arrestin-2–/– + AngII, n = 7. *P < 0.05 by Mann-Whitney test. d Representative images of VVG staining and quantification of elastin degradation. COMP–/– + AngII, n = 10; COMP–/–β-arrestin-2–/– + AngII, n = 6. *P < 0.05 by Mann-Whitney test. Scale bar, 50 μm.

Back to article page