Fig. 8: Schematic diagram of selective allosteric inhibition of AT1 signaling by COMP in pathogenesis of AAA. | Cell Research

Fig. 8: Schematic diagram of selective allosteric inhibition of AT1 signaling by COMP in pathogenesis of AAA.

From: Cartilage oligomeric matrix protein is an endogenous β-arrestin-2-selective allosteric modulator of AT1 receptor counteracting vascular injury

Fig. 8: Schematic diagram of selective allosteric inhibition of AT1 signaling by COMP in pathogenesis of AAA.

COMP, as an endogenous selective allosteric inhibitor of AT1 receptor, inhibits AngII-induced AT1-β-arrestin-2 signaling, but not G protein (Gq or Gi) signaling, thereby counteracting inflammatory vascular injuries. COMP directly binds to N-terminus of AT1 through its EGF2 domain, in a form that the C-terminus of COMP was placed in proximity to ECL1 of the AT1 receptor. β-Arr2, β-arrestin-2; ECL1, extracellular loop 1; ICL3, intracellular loop 3. COMP molecule: N, N-terminus; T3, type 3 repeats; C, C-terminus. AAA, abdominal aortic aneurysm.

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