Fig. 1: Cryo-EM structures of PACAP38-PAC1R-Gs and maxadilan-PAC1R-Gs.
From: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism
a, b Cryo-EM density map (left), the structure model (middle) and local resolution distribution map (right) of PAC1R-Gs in complex with PACAP38 (a) and maxadilan (b). The structures of PAC1R (green in PACAP38-PAC1R-Gs structure, orange in maxadilan-PAC1R-Gs structure), PACAP38 (pink), maxadilan (purple), Gα (red), Gβ (blue), Gγ (yellow) and Nb35 (gray) are represented in cartoon.
