Fig. 1: Replication-coupled DNA ICL repair pathways. | Cell Research

Fig. 1: Replication-coupled DNA ICL repair pathways.

From: A new varietal of DNA interstrand crosslink repair

Fig. 1

a The FA pathway repairs cisplatin ICLs via dual incisions in the phosphodiester backbone. The resulting double-strand break is fixed by inter-sister chromatid recombination. b The NEIL3 pathway cuts one of the two glycosyl bonds forming the ICL, generating an AP site in one strand and an ICL remnant in the other strand, both of which are bypassed by TLS. c Acetaldehyde ICLs are unhooked via direct reversal, generating a guanine in one strand and a propanoguanine in the other strand, which is bypassed by TLS.

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