Fig. 1: COMP, an endogenous negative allosteric modulator of βarr-dependent AT1AR signaling, offsets AAA development. | Cell Research

Fig. 1: COMP, an endogenous negative allosteric modulator of βarr-dependent AT1AR signaling, offsets AAA development.

From: Self-made allostery: endogenous COMP antagonizes pathologic AT1AR signaling

Fig. 1

a Within the abdominal aorta, COMP directly binds AT1AR at its N-terminus to allosterically antagonize pathological βarr2-dependent signaling. b During the development of AAA, COMP levels decrease, relieving the inhibition of βarr-dependent AT1AR pro-inflammatory signaling.

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