Fig. 1: LLPS facilitates NLRP6-mediated signaling.
From: It’s just a phase: NLRP6 phase separations drive signaling
Shen et al. show that NLRP6 binds dsRNA and undergoes LLPS to form a membraneless compartment in the cytosol that can serve as a starting point for multiple signaling pathways. NLRP6 activates IFN signaling to induce expression of IFNs and ISGs. In addition, ASC can be recruited to the NLRP6 complex, leading to caspase-1 (CASP1) activation and cleavage of pro-IL-18 to its bioactive form and GSDMD to release its N-terminal region (GSDMD-NT). IRFs, interferon regulatory factors.
