Fig. 7: The potential RNA substrate binding model of the m6A writer complex. | Cell Research

Fig. 7: The potential RNA substrate binding model of the m6A writer complex.

From: Cryo-EM structures of human m6A writer complexes

Fig. 7: The potential RNA substrate binding model of the m6A writer complex.

a s4U-crosslinking result of MAC/MACOM. b Renewed model of m6A writer complex in apo state (left panel) and RNA-methylation state (right panel) based on the HWVZ + M3/14 cryo-EM map and biochemistry data. Red star represents SAM. Green triangles in the right panel represent four s4U-crosslinking sites in a. Light-coral dash line represents N-terminus of METTL14. Purple and lavender dash lines represent N-terminus and linker between Zinc finger and MTA domain of METTL3, respectively. The models of SUN domain and C-terminus of VIRMA are colored in blue and lime-green, respectively.

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