Fig. 1: Proposed model for tRNA-m1A modification as a translational checkpoint for T cell proliferation. | Cell Research

Fig. 1: Proposed model for tRNA-m1A modification as a translational checkpoint for T cell proliferation.

From: tRNA-m1A modification: a translational checkpoint for T cell expansion

Fig. 1: Proposed model for tRNA-m1A modification as a translational checkpoint for T cell proliferation.The alternative text for this image may have been generated using AI.

Upon T cell activation, tRNAs and tRNA-m1A58 “writer” proteins (TRMT61A and TRMT6) are upregulated, resulting in an increased level of tRNA-m1A58 modification that facilitates MYC protein synthesis and thus promotes MYC-dependent cell proliferation.

Back to article page