Fig. 1: Nociceptors possess tissue-protective properties during homeostasis and intestinal inflammation. | Cell Research

Fig. 1: Nociceptors possess tissue-protective properties during homeostasis and intestinal inflammation.

From: How pain sensors make the gut weep

Fig. 1

(Left) Microbial products activate Nav1.8+ nociceptors, causing the release of CGRP. This neuropeptide in turn acts on goblet cells expressing RAMP1, the CGRP co-receptor, provoking the secretion of mucin. (Right) Ablation of Nav1.8+ nociceptors alters the microbiome composition in the gut during homeostasis and aggravates mucosal inflammation in a model of DSS-induced colitis.

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