Fig. 1: A cytosolic view of how a membrane-embedded βarr2 diffuses freely and encounters an agonist-stimulated GPCR to form a transient complex.

This short-lived association activates βarr2, which diffuses toward a CCP independently of the GPCR.

This short-lived association activates βarr2, which diffuses toward a CCP independently of the GPCR.