Fig. 2: Overall architecture and central cavity environment of OATP1B1.
From: Cryo-EM structures of human organic anion transporting polypeptide OATP1B1
a Overall architecture of outward-open OATP1B1-apo. NTD and CTD are colored in gold and marine, respectively. b Overall architecture of inward-open OATP1B1–Ein. c Multiple disulfide bonds formed by conserved cysteines within EL9–10 are shown as yellow sticks. A fragment of EL3–4 termed as N-lariat, is attached to EL9–10 via a disulfide bond. d Electropositive residues along the translocation path of outward-open OATP1B1-apo. e Slab view showing the conservation level of OATP1B1-apo using ConSurf. f Sliced view of the surface electrostatic potential of OATP1B1-apo. g Top view of key residues in the central cavity of outward-open OATP1B1-apo, forming electropositive, electronegative, and hydrophobic parts. Residues are shown as stick and colored based on ConSurf analysis.
