Fig. 1: Identification of DALT.

Immune cell aggregates, DALTs, are located along with sinuses. The largest structure was located at the rostral-rhinal venolymphatic hub. This structure is surrounded by fenestrated blood vessels and lymphatic vessels. Antigen or pathogen exposure initiates local immune response from the DALT. DALT contributes to the prevention of pathogen entry to the CNS. TS transverse sinus; SSS superior sagittal sinus. Created with BioRender.com.