Fig. 1: Broad H3K4me3 domains orchestrate temporal control of gene expression during sperm development.
From: Broad H3K4me3 domains orchestrate temporal control of gene expression
In spermatids, SETD1B is recruited by RFX2 and other transcription factors to stage-specific promoter and super-enhancer loci and mediates the formation of broad H3K4me3 domains. These broad H3K4me3 domains sequester more Pol II than sharp H3K4me3 peaks, thereby contributing to the transcriptional upregulation of stage-specific genes.
