Fig. 5: GluA1 expression in PL-dmPFC neurons increases synapse strength.
From: Social status impacts T-cell responses through synapse strength in the prefrontal cortex
a Representative traces, average mEPSC frequency, and mEPSC amplitude recorded from PL–dmPFC layer 5 neurons of WT (black, n = 24 cells), GRIA1-heterozygous (brown, n = 16 cells), and GRIA1-knockout (red, n = 21 cells) littermate mice. b AAV-mediated expression of GFP-GluA1 selectively in the PL-dmPFC of GRIA1−/− mice assessed by GluA1 immunostaining. Scale bars: left, 500 µm; right, 15 µm. c Representative traces, average mEPSC frequency, and mEPSC amplitude recorded from GFP-expressing PL–dmPFC layer 5 neurons of GRIA1−/− mice injected with AAV-GFP (green, n = 25 cells) or AAV-GFP-GluA1 (blue, n = 30 cells). Data are mean ± SEM. *P < 0.05, **P < 0.01, ****P < 0.0001. Statistics: one-way ANOVA with Tukey’s multiple-comparison test (a) and unpaired Student’s t-test (c).
