Fig. 7 | Cellular & Molecular Immunology

Fig. 7

From: Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin

Fig. 7

CD58 (on KCs) and CD2 (on T cells), not CD28 (on T cells), are detectable in the epidermis of psoriatic skin lesions. Representative immunohistochemical staining of punch biopsies of skin lesions from three different psoriasis patients, using an Opal-4-color IHC kit. a CD3 (green), CD58 (red), and DAPI (blue). For the secondary antibody (2nd AB) control, all reagents except the primary antibodies (αCD3 and αCD58) were used. b CD3 (green), CD28 (red), CD2 (yellow), and DAPI (blue). The dashed white line represents the border between the epidermis (E) and the dermis or a hair follicle. White triangles highlight epidermal T cells expressing CD2 but not CD28

Back to article page