Fig. 9 | Cellular & Molecular Immunology

Fig. 9

From: Jagged1-mediated myeloid Notch1 signaling activates HSF1/Snail and controls NLRP3 inflammasome activation in liver inflammatory injury

Fig. 9

Schematic illustration of JAG1-mediated myeloid Notch1/HSF1/Snail signaling in the regulation of innate immune responses during liver IRI. IR stress activates Notch1 signaling and induces ROS production in ischemic livers. Upon ligand binding, Notch1 is cleaved by γ-secretase and releases the intracellular domain (NICD), which translocates into the nucleus and forms a complex with the CSL DNA-binding protein to activate HSF1; HSF1, in turn, promotes Snail activation and regulates the TRX1/TXNIP and TRX1/ASK1 complexes, leading to reduced NLRP3 inflammasome activation and ROS-induced hepatocellular apoptosis/necrosis in IR-triggered liver inflammation

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