Fig. 1
From: Transcription tipping points for T follicular helper cell and T-helper 1 cell fate commitment
Tfh and Th1 fate trajectories. Naive CD4+ T cells following antigen presentation by dendritic cells and additional signals from the microenvironment develop into common Tfh/Th1 precursor cells that coexpress Bcl6 and T-bet, which are expressed competitively. In the presence of Tfh signals, common Tfh/Th1 precursor cells differentiate into Tfh cells that co-express key transcription factors (Bcl6 and T-bet), chemokine receptors (CXCR5 and CXCR3), and molecules (PD-1 and ICOS). In contrast, common Tfh/Th1 precursor cells that differentiate into Th1 cells in response to Th1 signals express the canonical Th1 transcription factors Blimp-1, T-bet, and Bcl6; chemokine receptors (CXCR3); and IL-2 receptor (IL-2RĪ±)
