Fig. 7 | Cellular & Molecular Immunology

Fig. 7

From: Taurocholic acid inhibits the response to interferon-α therapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8+ T and NK cell function

Fig. 7The alternative text for this image may have been generated using AI.

A model describing the mechanism regarding the inhibitory effect of taurocholic acid on the response to interferon-α therapy in patients with chronic hepatitis B. Compared with chronic hepatitis B (CHB) patients with low taurocholic acid (TCA) levels, CHB patients with high TCA levels had a lower number of CD3+CD8+ T and NK cells and lower levels of IFN-γ, TNF-α, granzyme B, and perforin secreted by CD3+CD8+ T and NK cells, resulting in the poor therapeutic response to pegylated interferon-alpha (PegIFNα) in CHB patients

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