Fig. 3
From: Impact of intracellular innate immune receptors on immunometabolism
Overview of intracellular innate immune receptors in T cell metabolic reprogramming. A HIV-1 infection increases the expression of NLRX1, which directly associates with FASTKD5 to promote OXPHOS and viral replication. B NLRC3 in T cells acts as an intrinsic attenuator that regulates T cell signaling pathways and metabolic progress to restrict autoimmune and virus-specific CD4+ T cell responses. C AIM2 facilitates the interaction between RACK1 and PP2A phosphatase, causing the dephosphorylation of AKT to restrain the activity of the mTOR pathway, thereby promoting Foxp3 expression and Treg cell stability
