Fig. 3
From: Metabolism of tissue macrophages in homeostasis and pathology
Microenvironmental influence on tissue macrophage metabolism. A Splenic red pulp macrophages scavenge defective erythrocytes for iron recycling. B Large peritoneal macrophages adapt their bioenergetics after detection of different microenvironmental factors, such as yeast, oxLDL or IL-4, to facilitate the respiratory burst. C Osteoclasts shift their cellular metabolism when exposed to bone, promoting bone resorptive activity. CI-III, complex I-III; FA, fatty acid; Gln, glutamine; IRP1, iron-responsive element-binding protein; PKC, protein kinase C; SO, superoxide; SZ, sealing zone. Solid lines: direct relationships; dashed lines: indirect relationships. Purple circles: cytokines; brown circles: bound cholesterol/LDL/oxLDL; red and orange stars: ROS, SO and H2O2
