Table 1 Phenotypes and functions of innate lymphoid cells in humans and mice
From: The unique role of innate lymphoid cells in cancer and the hepatic microenvironment
Group 1 ILCs | Group 2 ILCs | Group 3 ILCs | ||||
|---|---|---|---|---|---|---|
Subsets | NK cells | ILC1s | ILC2s | NCR+ ILC3s | NCR− ILC3s | LTi cells |
Effector function/mediators | IFN-γ, granzymes, perforin | IL-4, IL-5, IL-13, IL-9, AREG | IL-17, IL-22, GM-CSF | RANK, lymphotoxin, TNF-α, IL-17, IL-22 | ||
Transcription factors | T-BET, EOMES | T-BET, EOMESh | GATA3, RORα | RORγt, AhR | ||
Surface markers | ||||||
Mouse | CD49b, NK1.1, NKp46, KLRG1, CD122 | CD49a, NK1.1, NKp46, TRAIL, CD200R, CD122, CD127 | CD127, KLRG1, CD25, ST2 | CD127, NKp46, | CD127, CCR6, CD4 | CD127, CCR6 |
Human | CD16, CD56, NKp46, NKp30, NKp80, KLRG1, KIR, CD122, CD127 | NKp46, TRAIL, CD200R, CD122 CD49a, CD127 | CD127, KLRG1, CD25, CD161 | CD127, NKp46, CCR6, CD56, NKp44 | CD127, CCR6 | CD127, CCR6, CD7 |
