Fig. 1
From: Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis
Asscociations between SPHK1 and tumor-infiltrating lymphocytes and inhibitory biomarkers. a Differential expression of SPHK1 and SPHK2 across 16 cancer types compared with normal samples (identified by limma, |Log2(fold change)| >0.58, BH-adjusted p < 0.05). Pie charts in the right panel represent the percentage of cancer types with significant upregulation (red; UP), downregulation (blue; DN), and non-significant alteration (gray; NS). GO (b) and KEGG (c) functional analysis of differential expressed genes between papillary thyroid cancer cells with SHPK1 overexpression and control (GSE87307). GO enrichment was performed with upregulated genes by hypergeometric test, and KEGG enrichment was performed by the GSEA method. d Correlation between SPHK1 and the relative abundance of suppressive immune cell types including regulatory T cells (Tregs), myeloid-derived suppressor cells (MDSCs), and tumor-associated macrophages (TAMs). Pie charts in the right panel represent the percentage of cancer types with significantly positive (red; POS), negative (blue; NEG), and non-significant correlation (gray; NS). e Correlation between SPHK1 and inhibitory checkpoint gene expression in 33 cancer types. f Correlation between SPHK1 and CD274 across 33 cancer types from the TCGA database
