Fig. 1 | Cellular & Molecular Immunology

Fig. 1

From: New mechanism to promote long-term T-cell immunity by telomere transfer from antigen-presenting cells

Fig. 1

Telomere vesicle formation and transfer to T cells. Activation of APCs by ionomycin or the formation of immune synapses with T cells induces the degradation of shelterin, resulting in increased activation of TZAP and telomeric repeat sequences, which are encapsulated into telomere vesicles together with the protein Rad51. T cells acquire telomere vesicles to lengthen their telomeres, promoting their longevity

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