Fig. 4

CD155 is not associated with CD226 expression or prognosis value. A–C CD155 immunohistochemistry (original magnifications x20) and scale bar corresponding to 250 µm. A Nontumor liver tissue with diffuse membranous positivity in the bile ducts. B CRC metastasis with diffuse membranous tumor cell positivity. C CRC metastasis without tumor cell staining. D Patient repartition according to level of CD226 on CD8+ T cells and CD155 staining of tumor cells. No significant differences were observed between the groups. E RFS after hepatic surgery according to CD155 expression on tumor cells. + indicates weak expression, and + +/+++ indicates strong expression. On survival graphs, p based on the log-rank test. CRC Colorectal cancer; RFS Relapse-free survival