Table 1 Immunomodulatory and antibacterial effects of mesenchymal stem cells against various bacterial infections
From: Revisiting the role of mesenchymal stem cells in tuberculosis and other infectious diseases
Bacteria | Type of MSCs or component used | Effects | References |
|---|---|---|---|
Streptococcus pneumoniae | Mouse bone-marrow MSCs and MSC-conditioned media | Downregulation of pro-inflammatory cytokines IL-6, TNF-α, Upregulation of anti-inflammatory cytokine IL-10, Reduced Neutrophil infiltration, Reduced expression of Neutrophil chemoattractants CXCL1 and CXCL2. | [45] |
Klebsiella pneumoniae | Mouse bone marrow MSCs. | Reduced expression of TNF-α, decreases in IL-17 and IFN-γ+ T-cell subsets. | [48] |
E.coli | Mouse bone marrow MSCs Equine MSCs and MSC-conditioned media | Decrease in the proinflammatory mediators TNF-α and MIP2, increased expression of IL-10, increased expression of lipocalin2 Antibacterial effects due to cystatin C, lipocalin2, elafin, Cathelicidin | |
Staphylococcus aureus | Equine MSCs and MSC-conditioned media | Antibacterial effects due to cystatin C, lipocalin2, elafin, Cathelicidin Degradation of biofilms due to cathepsins Increased phagocytic activity of neutrophils. |
