Fig. 8 | Cellular & Molecular Immunology

Fig. 8

From: Targeting Lp-PLA2 inhibits profibrotic monocyte-derived macrophages in silicosis through restoring cardiolipin-mediated mitophagy

Fig. 8

Antifibrotic effect of the Lp-PLA2 specific inhibitor darapladib on silicotic mice. a Schematic diagram of silicotic mice treated with darapladib. b Lung function measurements of FRC, PEF, Cchord, and VC in mice from different experimental groups. n = 9 per group. c Lung tissue morphology and collagen deposition detected by HE and Masson staining; scale bar = 1 mm; zoom bar = 50 μm. d The protein expression levels of iNOS, Arg 1, IL-1β, and IL-6 in mouse lung tissues were examined via ELISA. n = 6 per group. e Western blot analysis was performed to detect the expression of Lp-PLA2, α-SMA and Col I in mouse lung tissues, n = 3. f Western blot analysis was performed to detect the expression of iNOS, Arg 1, IL-1β, and IL-6 in mouse lung tissues. n = 3 per group. The data are presented as the means ± SDs; *p < 0.05, **p < 0.01, ***p < 0.001, ns p ≥ 0.05

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