Fig. 3
From: Immunopathogenic mechanisms and immunoregulatory therapies in MASLD
The diverse roles of different immune cells in MASLD. Two subsets of EmKCs are identified in MASLD, including a major CD206loESAM- population (KC1) and a minor CD206hiESAM+ population (KC2), which have specific transcriptomic and proteomic signatures. Neutrophil-derived NETs exacerbate MASH-related liver fibrosis by inducing metabolic reprogramming of HSCs. NETs accelerate alcohol-induced acceleration of MASH-related liver fibrosis by activating HSCs and monocytes via NLRP3. Lymphocytes, including T cells, B cells, and innate lymphoid cells, play critical and diverse roles in MASLD
