Fig. 7: CTLA-4 upregulation on ILC2s is mediated by its ligands. | Cellular & Molecular Immunology

Fig. 7: CTLA-4 upregulation on ILC2s is mediated by its ligands.

From: Macrophages regulate PD-1 and CTLA-4 expression on ILC2s and their responsiveness in the tumor microenvironment

Fig. 7

A PD-1 and CTLA-4 expression on ILC2s after coculture with MoM with or without TW. B, C Representative FACS dot plots and histograms showing PD-1 and CTLA-4 expression on ILC2s after coculture in the presence of anti-CD80 and anti-CD86 Abs. D Experimental design (created in BioRender). CTLA-4 and PD-1 expression on ILC2s after coculture with MoM (E) or mPE macro (F) (D0) or 4 days post-culture (D4). The histograms show the percentage of positive cells expressed as the mean +/− SD of at least 5 (A) and 3 (C, E) independent experiments. FACS plots from one representative experiment out of 2 performed are shown in (F). One-way ANOVA was performed; NS not significant. *p < 0.05, **p < 0.01, ***p < 0.001

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