Fig. 11 | Cellular & Molecular Immunology

Fig. 11

From: Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns

Fig. 11The alternative text for this image may have been generated using AI.

Pyrin inflammasome. Under basal conditions, human and murine pyrin proteins are phosphorylated by the RhoA effector kinase PKN1/2 and bind to 14-3-3 proteins, maintaining them in an inactive state. Bacterial toxins, including Clostridium difficile TcdA and TcdB, inhibit RhoA activity and downstream PKN1/2-mediated phosphorylation, resulting in pyrin dephosphorylation and dissociation from 14-3-3 proteins. Activated pyrin then recruits ASC and caspase-1 to assemble a functional inflammasome complex

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